HUPO 2022 Speakers
This is your last chance to have your say at the 21st Annual HUPO Congress. Late Breaking Poster Abstract Submissions close today, September 23, 2022 (23:59 PDT). Submit your poster now at https://t.co/EqZxb7kHPDRead More
RT @CharlH_Science: Another fun panel done - thanks to everyone for attending and the panellists for their super useful advice. Keep an eye…Read More
Get to Know the Speakers
Meet the speakers for the HUPO 2022. In order to learn more about each individual speaker, please click on the photos below.
Main Congress Speakers
Steve is Professor of Proteomics at the UCD School of Medicine & Conway Institute in Dublin, Ireland. He graduated from Imperial College, London (Chemistry and Biochemistry) before completing a PhD in Biochemistry at the University of Cambridge. He was elected President of HUPO (www.hupo.org) (2019-2021) and recently received HUPO’s biennial distinguished service award. He is also the founder of the UCD spin out company Atturos (www.atturos.com).
Dr. Ying Ge is a Professor in the Department of Cell and Regenerative Biology and Department of Chemistry at University of Wisconsin-Madison. She received a B.S. from Peking University and a Ph.D. from Cornell University under the joint supervision of Prof. Fred McLafferty and Prof. Tadhg Begley. After graduate school, Dr. Ge explored a career in pharmaceutical industry. In 2012, Dr. Ge started her tenure-track Assistant Professor position, received tenure in 2015, and was promoted to Full Professor in 2019. Ge’s research is highly interdisciplinary that cuts across the traditional boundaries of chemistry, biology, and medicine. It is her belief that to make significant impact in molecular medicine, it is necessary to combine technology with function and bridge the silos between basic and translational/clinical research for precision medicine. Dr. Ge has devoted her past twenty years to developing and applying top-down mass spectrometry-based proteomics to biomedical research. Recently her lab has developed a multi-pronged approach to address the challenges in top-down proteomics. Dr. Ge has published over 150 papers with many in high impact journals. She has received a number of awards such as the ASMS Biemann Medal (2020), HUPO Clinical and Translational Proteomics Award (2021), and HPLC Society Georges Guiochon Faculty Fellowship (2016), as well as The Top 100 Analytical Scientist Power List (on a global scale, 2019, 2020 2021). Dr. Ge is passionate about education and has been mentoring students from chemistry, biology and medicine.
Dr. He is the leading scientist studying proteomics in China. He was the founder of CNHUPO and among the first group of people who founded HUPO in 2001. He was the first Chinese scientist who led an international consortium-Human Liver Proteome Project (HLPP), and the founder of Beijing Proteome Research Center, Phoenix Center (proteomics) and Institutes of Biomedical Sciences Fudan University. As the chief scientist, he has been propelling HLPP to the China Human Proteome Project (CNHPP), to create an encyclopedia of proteins in the human body under physiological and pathological conditions. In 2019, his team stratified early hepatocarcinoma (HCC) into 3 proteomic subtypes with different clinical outcome. Some drug targetable proteins have been demonstrated useful in identifying patients with HCC who could potentially benefit from targeted treatment in further clinical trials. These studies demonstrated the proteomic analysis as an independent powerful tool in cancer molecular subtyping, indicating that the era of “Proteomics Driven Precision Medicine (PDPM)” is coming. He is currently proposing a world-wide project called π-HuB (The Proteomic Navigator of the Human Body). It aims at playing a central and catalytic role in biomedical research over the next several decades and providing an ultimate solution at the molecular level for health and well-being of the humankind.
Benjamin A. Garcia obtained his BS in Chemistry at UC Davis in 2000, and then received his PhD in Chemistry in 2005 at the University of Virginia under Prof. Donald Hunt and then was an NIH NRSA Postdoctoral Fellow at the University of Illinois under Prof. Neil Kelleher from 2005-2008. From there Ben was appointed as an Assistant Professor in the Molecular Biology Department at Princeton University from 2008-2012, until his recruitment as the Presidential Associate Professor of Biochemistry and Biophysics at the University of Pennsylvania Perelman School of Medicine in 2012, promoted to full Professor in 2016, and named the John McCrea Dickson M.D. Presidential Professor in 2017. Ben moved in the summer of 2021 to the Washington University School of Medicine in St. Louis to become the Chair of the Department of Biochemistry and Molecular Biophysics. The Garcia lab has been developing and applying novel proteomic approaches and bioinformatics for interrogating protein modifications, especially those involved in epigenetic mechanisms such as histones during human disease, publishing over 350 publications. Ben has also been recognized with many honors and awards for his mass spectrometry research including The ASMS Biemann Medal and was named a Fellow of the Royal Society of Chemistry.
Anne-Claude Gingras is the Canada Research Chair in Functional Proteomics, the Lea Reichmann Chair in Cancer Proteomics and a Senior Investigator at the Lunenfeld-Tanenbaum Research Institute, Sinai Health System. A Full Professor in the department of Molecular Genetics at the University of Toronto, she also serves as as deputy editor of Molecular and Cellular Proteomics and as a co-director of the Network Biology Collaborative Centre (a Genome Canada technology platform). Her lab focuses on the study of signalling pathways using systematic approaches and the development of quantitative proteomics technologies. She has developed computational tools that enable better analysis and visualization of proteomics results, and contribute to training the next generation of proteomics researchers. Using the tools that she developed, her group has identified new protein complexes and signaling components that provide a better understanding of perturbations associated with cancer and rare diseases. She also contributed to Canada’s response to the COVID-19 pandemic by developing high-throughput serology assays. Dr. Gingras has published >275 research articles and review articles that have already been cited 47K times.
Prof Nicki Packer has had an extensive and varied research career in both Chemistry and Biological Sciences. She helped establish the Australian Proteome Analysis Facility (APAF) and co-founded Proteome Systems Ltd, a biotechnology company in which her group developed glycoanalytical technology and informatics tools. She has gained national and international recognition for her research in glycomics, using proteomics and bioinformatics approaches and linking it to biological functional research. Her current research is in the structure, function, informatics and application of glycans and their conjugates as molecular markers, focusing on their role in cancer, therapeutics and microbial infection. Nicki currently holds positions as Distinguished Professor of Glycoproteomics, and is a Chief Investigator in two ARC Centres of Excellence (NanoScale BioPhotonics and Synthetic Biology), is Academic Lead of APAF at Macquarie University, Sydney, and is a Principal Research Leader at the Institute for Glycomics, Griffith University, Australia. Her research role in all her work is directed towards the role of protein glycosylation in health and disease; specifically her current projects encompass the analysis and role of glycosylation in many systems including the i) function of glycans attached to glycoproteins and glycolipids, ii) cell membrane glycosylation interactions, iii) glycans as targets for bioimaging, diagnosis and drugs, iv) the mucin glycome-microbiome interactions. She has also raised three (reasonably well-balanced) children…..
Marius Ueffing has developed research strategies to combine bioanalytic, proteomic, functional genomics and computational research towards investigation of disease mechanisms and markers. His specific focus lies on the identifications of molecular mechanisms of disease as perturbation of protein networks, the identification of biomarkers for human neurodegenerative diseases and the identification of genes/proteins associated with neurological and retinal diseases.
He is the Director of the Institute for Ophthalmic Research at the University Medical Center in Tuebingen. He directs the Medical Proteome Center, a core facility of the medical faculty in Tübingen and has been a co-founder of QBiC, the Quantitative Biology Center of the University of Tuebingen. His previous positions included that of a Research Associate at Columbia University, College of Physicians and Surgeons, New York, followed by group leader positions in pharmaceutical industry at Goedecke-Parke-Davis and in the Division of Medical Genetics at the University Medical Centre Munich. Before and jointly with his appointment to Tübingen, he was Director of the Independent Research Unit/Division of Protein Science at the National Research Centre for Environment and Health in Munich. He has coordinated several research consortia funded by the German government focusing on the development of proteomics technology as well as two EU consortia (EU 7thFW SYSCILIA and the EU Horizon2020 Systems Medicine Project EYE-RISK). In 2019 he received the HUPO Clinical and Translational Proteomics Award.
In 1994 Marc Wilkins developed the concept of the proteome and coined the term. In 1997 he co-wrote and co-edited the first book on proteomics. Since that time, Marc has published >250 peer-reviewed research papers, review papers and book chapters and has edited 2 books in the field of proteomics, genomics and systems biology. In proteomics, a recent focus has been to construct a complete methylproteome network in a model organism, and to study its regulatory properties. In genomics, recent highlights have included the sequencing and assembly of the koala genome and collaborative work in the RNA atlas project.
In industry, Marc has co-founded two biotechnology companies. Proteome Systems Limited (1999), in which he worked for 6 years, was a proteomics diagnostics and technology development company. Regeneus (2007) is a regenerative medicine company that recently licensed its core product to a Japanese multinational. At UNSW, Marc is a Professor of Systems Biology. He has been Director of the Ramaciotti Centre for Genomics since 2011 and has grown that to be the largest such facility at any Australian university.
Marc is an elected member of the Council of HUPO, and was a co-organiser of HUPO2010 in Sydney and then HUPO2019 in Adelaide. Marc also serves as an elected member of the Australian Proteomics Society’s Committee of Management.
Ileana Cristea is the Henry L. Hillman Professor in Molecular Biology at Princeton University. Her laboratory investigates mechanisms of cellular defense during infection with human viruses. Towards this goal, she has promoted the integration of virology with proteomics and bioinformatics. She has developed methods for studying spatial and temporal virus-host protein interactions, bridging developments in mass spectrometry to important findings in virology. For example, her laboratory has contributed to the emergence of the research field of nuclear DNA sensing in immune response, to uncovering mechanisms underlying organelle remodeling and organelle structure-function relationships during infections, and to the discovery of sirtuins as broad-spectrum antiviral factors. Dr. Cristea is the Past-President of the American Human Proteome Organization (US HUPO), the past-chair of the Biology/Disease-driven Human Proteome Project (B/D-HPP) of HUPO, and the Chair of the Infectious Disease team of HUPO B/D-HPP. She has taught the summer Proteomics Course at Cold Spring Harbor Laboratory for over ten years, and is Senior Editor for mSystems, Associate Editor for the Journal of Proteome Research and on the Editorial Boards of Molecular Systems Biology and Molecular & Cellular Proteomics. She was recognized with the Bordoli Prize from the British Mass Spectrometry Society (2001), NIDA Avant-Garde Award for HIV/AIDS Research (2008), Human Frontiers Science Program Young Investigator Award (2009), Early Career Award in Mass Spectrometry from ACS (2011), ASMS Research Award (2012), Molecular Cellular Proteomics Lectureship (2013), Mallinckrodt Scholar Award (2015), Discovery Award in Proteomic Sciences at HUPO (2017), and the Princeton University Graduate Mentoring Award (2020).
The major research foci of György Marko-Varga are clinical studies, drug characterisation within Cancerous disease and Biobanking.
GYORGY is the Head of the European Cancer Moonshot Lund Center, with a focus on Melanoma and Lung Cancer.
Malignant Melanoma is the most frequently mutated tumor type with approx 50% of the cases harbor activating BRAF mutations, that is the key driver. Large scale studies are undertaken in multi-center studies, currently establishing the largest Molecular Pathology database with 700 patients and resulting 65 million sequence files, where most WHO Melanoma classes have been mapped and characterized.
We have developed digital pathology image libraries, establishing a morphology index pathology basis with a single cell annotation resolution, targeting clone specificificity of Melanoma cancer cell types, as well as stromal phenotypes that interplay and generates an initiation of the Metastasis spread.
ProteoGenomics expression on whole tumor sections, tumor compartments, and clone specific expressions are generated – adressing metastasis activation and developments, as well as mode-of-drug-action mechanisms, and the challenges realting to resistence and Cancer relapses.
Our major objective within the European Cancer Moonshot Center is to build medical knowledge on an individual patient basis by applying ProteoGenomics positioned in the heart of Cancer clinics, collaborating with oncologists, surgery and pathologists.
PhD, Indian Institute of Science, 1997. Postdoctoral researcher, Oxford University, UK, 1997-2000. At EMBL-EBI since 2000.
More information on the team – https://www.ebi.ac.uk/about/teams/pdbe/
Dr. Melvin Park is Director of Research at Bruker Daltonics. He received his bachelor’s degrees in Chemistry and Physics from NC State University in 1986 and a Ph.D. in Chemistry from Texas A&M in 1991. His dissertation centered on secondary ion mass spectrometry, coincidence counting, and time-of-flight mass spectrometry, and their application to surface analysis. After postdoctoral studies at the Naval Research Laboratories in 1993 regarding MALDI TOF, he joined Bruker. Over the past nearly three decades he and his colleagues have produced more than 80 issued patents and 30 peer reviewed journal articles in all areas of mass spectrometry and, more recently, ion mobility spectrometry. The most well-known of these is trapped ion mobility spectrometry (TIMS). His current work is the continued advancement and application of mass spectrometry, TIMS, and their peripherals.
Glycoinformatics researcher since 2003, responsible for the glycan repository GlyTouCan, the glycomics MS repositories GlycoPOST (raw data) and UniCarb-DR (glycans), which are all accessible from the glycoscience Web portal GlyCosmos.
Jean Armengaud is specialized in mass spectrometry for biology and more specifically in proteogenomics and metaproteomics. He manages the ProGénoMIX platform located near Avignon in France. He wishes to contribute to a better understanding of the functioning of complex biological systems and exploit this knowledge for medical and environmental purposes. He received his PhD in Biochemistry in 1994 at the University of Grenoble.
Since 2019 Ben is a Reader (equiv. Assoc. Prof.) in the the School of Biological Sciences, Queen’s University of Belfast, UK. His research focuses on broadly on 3 topics: (i) method development and applications in data independent acquisition mass spectrometry; (ii) method development and applications in the analysis of protein interaction networks and protein complexes; and (iii) applications of these strategies in host-pathogen biology and innate immunity. Ben’s PhD was completed at University College Dublin in 2009 where he remained for 1 year as the Agilent Technologies Newman Fellow (postdoctoral) in Quantitative Proteomics. Ben moved to the Institute of Molecular Systems Biology at ETH Zurich in Autumn 2010 as postdoctoral researcher under the supervision of Prof. Ruedi Aebersold, where his research focused on the application of quantitative interaction proteomics in signaling and the development of DIA/SWATH mass spectrometry. Following this Ben was a Group Leader and SNF Ambizione Fellow at IMSB, ETH Zurich with a focus on applying methods developed as a postdoc to relevant problems in host-pathogen biology.
Michael Angelo, MD PhD is a board-certified pathologist in the department of Pathology at Stanford University School of Medicine. Dr. Angelo is a leader in high dimensional imaging with expertise in tissue homeostasis, tumor immunology, and infectious disease. His lab has pioneered the construction and development of Multiplexed Ion Beam Imaging by time of flight (MIBI-TOF). MIBI-TOF uses secondary ion mass spectrometry and metal-tagged antibodies to achieve rapid, simultaneous imaging of dozens of proteins at subcellular resolution. His lab has used this novel technology to discover previously unknown rule sets governing the spatial organization and cellular composition of immune and stromal cells within the tumor microenvironment in triple negative breast cancer and ductal carcinoma in situ. This effort has led to ongoing work aimed to define broader structural mechanisms that promote tolerogenic niches in cancer, tuberculosis, and the maternal fetal interface. Dr. Angelo is the recipient of 2014 NIH Director’s Early Independence, 2020 DOD Era of Hope Award and is a principal investigator on multiple extramural awards from the National Cancer Institute, Breast Cancer Research Foundation, Parker Institute for Cancer Immunotherapy, the Bill and Melinda Gates Foundation, and the Human Biomolecular Atlas (HuBMAP) initiative.
I am an Assistant Professor at Cedars-Sinai Heart Institute, with a broad background of biochemistry, molecular biology, immunology, and proteomics to study organ function and regulation in health and disease. My research involves inter-institutional collaborations focused on identifying novel and/or largely understudied biologic markers of heart failure (HF) with the major role of proteins posttranslational modifications (PTMs). I am pioneer in the understanding of arginine deiminases, enzymes family that introduce PTM, called citrullination and their contributions to many processes, like aging, inflammation, and their link with disease development and progression. Uncovering these biological bases are long term goals of my lab expanding to other physiological or pathological conditions. In fact, the COVID-19 pandemic experience has profoundly impact research at my lab and our work has been focuses on i) sex and race differences in both susceptibility and response to SARS-CoV-2 exposure and response to SARS-COV-2 infection; ii) sex and race differences in both positive and negative response to SARS-CoV-2 vaccine, and iii) linking adaptive immune response – autoimmunity with Long COVID, post-acute sequelae of SARS-CoV-2 infection. The concept of profiling autoantibodies in healthy and disease patients combined with multi-omic data will form the basis of disease prediction allowing for earlier intervention linked to disease prevention strategies, as well as earlier, effective and personalized interventions for established disease.
Dr. Jennifer Geddes-McAlister started her appointment as Assistant Professor in the Department of Molecular and Cellular Biology at the University of Guelph in July 2018. She is an expert in mass spectrometry-based proteomics following a Alexander von Humboldt post-doctoral fellowship at the Max Planck Institute of Biochemistry (Germany). Her research program aims to define the relationship between host and pathogen during infection to uncover new strategies for overcoming resistance in both medically- and agriculturally-relevant diseases. Dr. Geddes-McAlister is the elected Vice President, Communications and Board member for the Canadian National Proteomics Network (CNPN), co-Founder of the Canadian Proteomics and Artificial Intelligence Research and Training Consortium (CanProAI), and the elected Western Hemisphere Diversity Candidate for the Human Proteome Organization (HUPO). She recently founded ‘Moms in Proteomics’, an initiative dedicated to mentoring and supporting mothers in STEM and foudnded the CNPN Unity initiative to promote equity, diversity, and inclusion in proteomics research and training across Canada.
Anjali Seth studied Physics and Chemistry in Paris. She obtained her PhD from Pierre and Marie Curie University for her research on magnetic nanoparticles for targeted drug delivery and imaging. She then moved to Oxford, UK, for a postdoctoral project on magnetic particles and ultrasound for cancer theranostics. In 2019, she joined Cellenion, a company specialized in the field of single-cell isolation, to develop and lead the single cell proteomics R&D department. Since then, she had the opportunity to participate in the advancement of the cutting-edge field of single cell proteomics analyses using mass spectrometry. In Cellenion, she focuses on developing tools to facilitate and automate sample preparation workflows prior to analysis. Cellenion is now collaborating with most of the key opinion leader in the field.
Albert J.R. Heck (Utrecht University, The Netherlands) is scientific director of the Netherlands Proteomics Centre. Heck’s group emphasizes on the development and applications of advanced mass spectrometry-based proteomics technologies. Heck introduced TiO2 and Ti4+-IMAC based technologies for phospho-enrichment. Heck pioneered the use of alternative proteases and hybrid peptide fragmentation techniques (e.g. EThcD, UVPD). His group also introduced 15N labeling in multicellular organisms and the cost-effective dimethyl labeling. Heck’s proteomics research focuses for a large part on cancer, stem cells and immunology. Besides the proteomics efforts, the group of Heck is also well known for its expertise in mass spectrometry based structural biology, using native mass spectrometry, cross-linking and/or HD exchange mass spectrometry. The Heck-lab developed dedicated instruments for the analysis of intact proteins and protein complexes, with most recently a new high-mass Orbitrap, a serious breakthrough for top-down proteomics and native mass spectrometry. Through the development of the XlinkX and PhoX workflows they also facilitated proteome wide cross-linking studies. In recent years he has also focused on analyzing biopharmaceuticals, and plasma glycoproteins and immunoglobulins.
Heck is recipient of the HUPO Discovery Award (2013), and the Proteomics Pioneer Award from the European Proteomics Association (EuPA, 2014). In 2016 he received the ACS Field and Franklin Award. In 2014 he became elected member of EMBO and the Royal Netherlands Academy of Sciences and Arts (KNAW). In 2017 Heck received the Spinoza Prize, the most distinguished scientific award in the Netherlands. In 2018 Heck received the Thomson medal of the International Mass Spectrometry Society and the Krebs medal (FEBS), in 2021 the Pittcon Wallace H. Coulter Award.
Manuel Mayr is the British Heart Foundation (BHF) Professor for Cardiovascular Proteomics. He qualified in Medicine from the University of Innsbruck (Austria) in 1999. He then moved to London to undertake a PhD on combining proteomics and metabolomics. Upon completion of his PhD in 2005, he achieved promotion to Professor at King’s College London in 2011. In 2017, he has been awarded a BHF Personal Chair.
His group uses proteomics in combination with other -omics technologies to integrate biological information in disease-specific networks that drive pathophysiological changes. While studying molecular interactions has been a research focus for many years and has provided important insight into biology, the attention has now shifted towards a more integrative network biology approach (Nat Rev Cardiol. 2021;18(5):313-330). He has published more than 275 peer review scientific papers. He is Consulting Editor for JMCC and Circulation, Associated Editor for Atherosclerosis and Cardiovascular Research and serves on the editorial boards of Circ Res, ATVB and Mol Cell Proteomics.
His academic achievements have been recognised by the inaugural Michael Davies Early Career Award of the British Cardiovascular Society (2007), the inaugural Bernard and Joan Marshall Research Excellence Prize of the British Society for Cardiovascular Research (2010), the Outstanding Achievement Award by the European Society of Cardiology (ESC) Council for Basic Cardiovascular Science (2013) and most recently the President’s Distinguished Lecture of the International Society for Heart Research (ISHR, 2022).
Lisa M. Jones is a Professor in the Department of Chemistry and Biochemistry at the University of California San Diego. She received her BS from the Department of Chemistry at Syracuse University and her PhD in Chemistry from Georgia State University. She received postdoctoral training in structural virology at the University of Alabama- Birmingham and in MS-based protein footprinting at Washington University in St. Louis. Dr. Jones’s research interests include the use of the protein footprinting method fast photochemical oxidation of proteins (FPOP) coupled with mass spectrometry for the characterization of the higher order structure of proteins. In particular, her lab has further developed the FPOP method for in-cell (IC-FPOP) studies for proteome-wide structural biology. Biological applications of IC-FPOP include characterizing protein folding intermediates directly in the cell and drug target (both on and off targets) determination. The Jones lab has also extended the method for in vivo analysis (IV-FPOP) in C. elegans. This provides the ability to study protein structure in an animal model for human disease.
I obtained a Computer Science degree in 2011 and a PhD in 2016 working in the field of Artificial Intelligence applied to the analysis of mass spectrometry data at Universidade de Vigo, under Dr. Daniel Glez-Peña and Dr. Miguel Reboiro-Jato supervision. The combination of Artificial Intelligence with Life sciences (especially Bioinformatics) defines my main research line since then. I have being member of the SING research group (Next Generation Computer Systems Group) since 2012 and I am currently working as Postdoctoral Researcher at the Informatics Department of Universidade de Vigo. I collaborate with the Phenotypic Evolution research group at Instituto de Investigação e Inovação (Porto, Portugal), where I worked as Junior Researcher between May and December 2021. I am also specialized in the development of scientific software applications (mainly in Java) and data analysis (R, Python), with special interest on the creation of automated analysis pipelines.
Isabell Bludau is a postdoctoral fellow in the lab of Prof. Matthias Mann at the Max Planck Institute of Biochemistry near Munich. She is specialized in computational proteomics and systems biology. During her PhD with Prof. Ruedi Aebersold at ETH Zurich, Isabell developed computational methods for analyzing large-scale proteomics data. She specifically worked on the detection and quantification of protein complexes and the inference of proteoform groups from bottom-up proteomics data. Recently, Isabell’s work focuses on investigating post-translational modifications in their 3-dimensional context. Isabell’s PhD thesis was awarded with the ETH silver medal and her postdoctoral research is supported by a Postdoc.Mobility fellowship of the Swiss National Science Foundation. Next to her research, Isabell is a member of the organizing committee of the ISCB’s Community of Special Interest on Computational Mass Spectrometry and she is part of the HUPO Early Career Researcher Initiative.
Cheng Chang received his B.E. in Electronic Engineering from Hunan University, China, in 2010 and received in his Ph.D. in Bioinformatics from Beijing Proteome Research Center, China, in 2015. Currently, he is an associate research fellow in Department of Biomedical Big Data, Beijing Proteome Research Center and National Center for Protein Sciences (Beijing). His major research interests include proteomics, bioinformatics, and precision medicine.